Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders:comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110562" target="_blank" >RIV/00843989:_____/23:E0110562 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/23:A2402NOS

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnhum.2023.1284416/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Human_Neuroscience&id=1284416" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnhum.2023.1284416/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Human_Neuroscience&id=1284416</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnhum.2023.1284416" target="_blank" >10.3389/fnhum.2023.1284416</a>

Result language

angličtina

Original language name

Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders:comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers

Original language description

Background: Serum neurofilament light chain (S NfL) is a non-specific marker of neuronal damage, including Alzheimer’s disease (AD). We aimed to verify the reference interval (RI) of serum NfL using a highly sensitive ELISA, and to estimate the optimal cut-off value for neuronal damage. Our second objective was to compare NfL in cerebrospinal fluid (CSF) and serum (S) with the routine neurodegeneration biomarkers used in AD, and to assess their concentrations relative to the degree of cognitive deficit. Methods: Samples from 124 healthy volunteers were used to estimate the S NfL RI. For the comparison study, we used CSF and S samples from 112 patients with cognitive disorders. Cognitive functions were assessed using the mini-mental state examination. ELISA assays were used to determine the CSF and S NfL levels, CSF ß-amyloid peptide42 (Aß42), CSF ß-amyloid peptide40 (Aß40), CSF total tau protein (tTau), CSF phosphorylated tau protein (pTau), and CSF alpha-synuclein (?S). Results: The estimated RI of S NfL were 2.25–9.19 ng.L–1. The cut-off value of S NfL for assessing the degree of neuronal impairment was 10.5 ng.L–1. We found a moderate statistically significant correlation between S NfL and CSF Aß42 in the group with movement disorders, without dementia (rs = 0.631; p = 0.016); between S NfL and CSF Aß40 in the group with movement disorder plus dementia (rs = -0.750; p = 0.052); between S NfL and CSF tTau in the control group (rs = 0.689; p = 0.009); and between S NfL and CSF pTau in the control group (rs = 0.749; p = 0.003). The non-parametric Kruskal–Wallis test revealed statistically significant differences between S NfL, CSF NfL, CSF Aß42, CSF tTau, and CSF pTau and diagnosis within groups. The highest kappa coefficients were found between the concentrations of S NfL and CSF NfL (? = 0.480) and between CSF NfL and CSF tTau (? = 0.351). Conclusion: Our results suggested that NfL and tTau in CSF of patients with cognitive decline could be replaced by the less...

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in human neuroscience

ISSN

1662-5161

e-ISSN

1662-5161

Volume of the periodical

17

Issue of the periodical within the volume

article 1284416

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

1-11

UT code for WoS article

001131708300001

EID of the result in the Scopus database

2-s2.0-85180881475