Chitinase-3-like 1 protein (CHI3L1) levels in patients with cognitive deficits and movement disorders: comparison with other biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111733" target="_blank" >RIV/00843989:_____/25:E0111733 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/25:A2603C2W RIV/61989100:27240/25:10260024

Result on the web

<a href="https://doi.org/10.1002/brb3.70619" target="_blank" >https://doi.org/10.1002/brb3.70619</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/brb3.70619" target="_blank" >10.1002/brb3.70619</a>

Result language

angličtina

Original language name

Chitinase-3-like 1 protein (CHI3L1) levels in patients with cognitive deficits and movement disorders: comparison with other biomarkers

Original language description

Introduction: Chitinase-3-like protein 1 (CHI3L1) is a glycoprotein implicated in various neurological conditions. It is associated with neuroinflammation and tissue remodeling. The study aimed to validate the reference interval (RI) of serum (S) CHI3L1 in a control group, to correlate S CHI3L1 values with other biomarkers of neurodegenerative damage, and to estimate the diagnostic accuracy of S CHI3L1. Methods: Samples from 108 healthy volunteers were used to estimate the S CHI3L1 RI. For the comparison, we used cerebrospinal fluid (CSF) and serum (S) samples from 121 patients with cognitive disorders, and cognitive deterioration was assessed using the Mini-Mental State Examination (MMSE). ELISA assays were used to determine the S CHI3L1, CSF, and S neurofilament light chain (NfL) levels; CSF and plasma ß-amyloid peptide42; CSF and plasma ß-amyloid peptide40; CSF total tau protein; CSF phosphorylated tau protein; and CSF alpha-synuclein. Results: The estimated RI of S CHI3L1 was 14.44 to 63.11 µg/L. The cut-off value of S CHI3L1 was 34.37 µg/L. ROC analysis showed that S CHI3L1 has 81.4% sensitivity and 76.9% specificity. We found a moderate Spearman's rank correlation coefficient between the S CHI3L1 and age (rS = 0.486; p < 0.001) and between S CHI3L1 and S NfL (rS = 0.489; p < 0.001) in all groups. The Kruskal-Wallis test showed a significant overall difference in S CHI3L1 among diagnostic groups (p = 0.013). S CHI3L1 and CSF NfL had statistically significant effects on MMSE values (multiple R2 was 0.431). Conclusions: Our results suggest that S CHI3L1 reflects the severity of cognitive deficits assessed by MMSE. It can be used as a supportive biomarker in neurodegenerative diseases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain and behavior

ISSN

2162-3279

e-ISSN

2162-3279

Volume of the periodical

15

Issue of the periodical within the volume

article e70619

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1-11

UT code for WoS article

001507715500001

EID of the result in the Scopus database

2-s2.0-105007935078