Analysis of serum concentrations of metoprolol and its metabolite alpha-hydroxymetoprolol in patients with heart failure with reduced ejection fraction: a pilot study in routine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111517" target="_blank" >RIV/00843989:_____/25:E0111517 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/epdf/10.1080/17512433.2025.2450257?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/epdf/10.1080/17512433.2025.2450257?needAccess=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17512433.2025.2450257" target="_blank" >10.1080/17512433.2025.2450257</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of serum concentrations of metoprolol and its metabolite alpha-hydroxymetoprolol in patients with heart failure with reduced ejection fraction: a pilot study in routine
Original language description
Background: The cardioselective ß-1 receptor antagonist metoprolol is used to treat heart failure. It is metabolized in the liver, primarily by cytochrome 2D6. Research design and methods: In this study, trough serum concentrations of metoprolol and its metabolite ?-hydroxymetoprolol were measured in patients with heart failure with reduced ejection fraction. Results: Concentrations were 1.3-122.9 µg/L for metoprolol and 1.3-125.7 µg/L for ?-hydroxymetoprolol, metabolic ratios were 0.11-98.32. The median weight-adjusted apparent clearance of metoprolol was 53.07 (range 3.24-500.0). Metoprolol and ?-hydroxymetoprolol concentrations correlated with both daily dose and dose per kilogram of body weight. However, metoprolol concentrations at the same daily dose showed a wide variability. Patients taking 100 mg/day had significantly lower NT-proBNP values than those taking 25 or 50 mg/day. Patients with LVEF ? 35% versus > 35% used significantly lower daily doses and doses per kilogram of body weight, although metoprolol concentrations did not differ. A poor cytochrome 2D6 metabolizer phenotype was detected in two patients. Conclusions: Metoprolol concentrations showed a wide interindividual variability at the same daily dose. Simultaneous determination of metoprolol and ?-hydroxymetoprolol concentrations could identify patients at risk of possible accumulation of metoprolol leading to intoxication or, conversely, patients at risk of underdosing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert review of clinical pharmacology
ISSN
1751-2433
e-ISSN
1751-2441
Volume of the periodical
18
Issue of the periodical within the volume
1-2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
89-99
UT code for WoS article
001398961400001
EID of the result in the Scopus database
2-s2.0-85215326767