Analysis of serum concentrations of metoprolol and its metabolite α-hydroxymetoprolol in patients with heart failure with reduced ejection fraction: a pilot study in routine health care
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603AIE" target="_blank" >RIV/61988987:17110/25:A2603AIE - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/17512433.2025.2450257" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17512433.2025.2450257</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17512433.2025.2450257" target="_blank" >10.1080/17512433.2025.2450257</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of serum concentrations of metoprolol and its metabolite α-hydroxymetoprolol in patients with heart failure with reduced ejection fraction: a pilot study in routine health care
Original language description
BackgroundThe cardioselective beta-1 receptor antagonist metoprolol is used to treat heart failure. It is metabolized in the liver, primarily by cytochrome 2D6. Research design and methodsIn this study, trough serum concentrations of metoprolol and its metabolite alpha-hydroxymetoprolol were measured in patients with heart failure with reduced ejection fraction. ResultsConcentrations were 1.3-122.9 mu g/L for metoprolol and 1.3-125.7 mu g/L for alpha-hydroxymetoprolol, metabolic ratios were 0.11-98.32. The median weight-adjusted apparent clearance of metoprolol was 53.07 (range 3.24-500.0). Metoprolol and alpha-hydroxymetoprolol concentrations correlated with both daily dose and dose per kilogram of body weight. However, metoprolol concentrations at the same daily dose showed a wide variability. Patients taking 100 mg/day had significantly lower NT-proBNP values than those taking 25 or 50 mg/day. Patients with LVEF <= 35% versus > 35% used significantly lower daily doses and doses per kilogram of body weight, although metoprolol concentrations did not differ. A poor cytochrome 2D6 metabolizer phenotype was detected in two patients. ConclusionsMetoprolol concentrations showed a wide interindividual variability at the same daily dose. Simultaneous determination of metoprolol and alpha-hydroxymetoprolol concentrations could identify patients at risk of possible accumulation of metoprolol leading to intoxication or, conversely, patients at risk of underdosing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
ISSN
1751-2433
e-ISSN
1751-2441
Volume of the periodical
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Issue of the periodical within the volume
1-2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
89-99
UT code for WoS article
001398961400001
EID of the result in the Scopus database
2-s2.0-85215326767