Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F10%3AA110109A" target="_blank" >RIV/61988987:17110/10:A110109A - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
Original language description
Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state.Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
česká a slovenská farmacie
ISSN
1210-7816
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
59
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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