Embryos and embryonic stem cells from the white rhinoceros.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F08568901%3A_____%2F18%3AN0000003" target="_blank" >RIV/08568901:_____/18:N0000003 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-018-04959-2" target="_blank" >https://www.nature.com/articles/s41467-018-04959-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-018-04959-2" target="_blank" >10.1038/s41467-018-04959-2</a>

Result language
angličtina
Original language name
Embryos and embryonic stem cells from the white rhinoceros.
Original language description
The northern white rhinoceros (NWR, Ceratotherium simum cottoni) is the most endangered mammal in the world with only two females surviving. Here we adapt existing assisted reproduction techniques (ART) to fertilize Southern White Rhinoceros (SWR) oocytes with NWR spermatozoa. We show that rhinoceros oocytes can be repeatedly recovered from live SWR females by transrectal ovum pick-up, matured, fertilized by intracytoplasmic sperm injection and developed to the blastocyst stage in vitro. Next, we generate hybrid rhinoceros embryos in vitro using gametes of NWR and SWR. We also establish embryonic stem cell lines from the SWR blastocysts. Blastocysts are cryopreserved for later embryo transfer. Our results indicate that ART could be a viable strategy to rescue genes from the iconic, almost extinct, northern white rhinoceros and may also have broader impact if applied with similar success to other endangered large mammalian species.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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