Activation of membrane-located Ca2+ channels by hop beta acids and their tricyclic transformation products

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F14864347%3A_____%2F19%3AN0000001" target="_blank" >RIV/14864347:_____/19:N0000001 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0308814618300815?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0308814618300815?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.foodchem.2018.01.073" target="_blank" >10.1016/j.foodchem.2018.01.073</a>

Result language

angličtina

Original language name

Activation of membrane-located Ca2+ channels by hop beta acids and their tricyclic transformation products

Original language description

Beta-bitter acids of hops (lupulones) revealed sedative and antidepressant–like effects in animal studies. Transformation of β-acids during beer brewing leads to the formation of tricyclic transformation products, which have a close structural analogy to hyperforin. The latter compound is responsible for the antidepressant activity of St. John’s wort by activation of TRPC6 cation channels in neuronal-like cells leading to Ca2+ influx. In this study, nortricyclolupones, dehydrotricyclolupones, and tricyclolupones were isolated from a wort-boiling model and their structures were elucidated by UHPLC–DAD, UHPLC–ESI−-MS/MS and 1D/2D-NMR spectroscopy. Beta-bitter acids and their transformation products induced Ca2+ influx in PC12 cells to the same extent as hyperforin. Application of a Ca2+-free environment abolished the Ca2+ elevation, indicating that the increase is mediated by influx across the plasma membrane. Thus, activation of neuronal-like Ca2+-channels by lupulones and tricyclolupones represent a novel mechanism contributing to the antidepressant activity of hops.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40101 - Agriculture

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food Chemistry

ISSN

0308-8146

e-ISSN

—

Volume of the periodical

252

Issue of the periodical within the volume

30 June 2018

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

215-227

UT code for WoS article

000426646500027

EID of the result in the Scopus database

—