Molecular classification of gastric cancers by parallel examination of multiple gene amplifications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F14%3A%230000204" target="_blank" >RIV/26475821:_____/14:#0000204 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Molecular classification of gastric cancers by parallel examination of multiple gene amplifications
Original language description
Poster describing a molecular classification of gastric cancers by parallel examination of multiple gene amplifications. Gastric cancer is characterized by heterogeneity in morphology as well as on the molecularlevel resulting in diverse response to anticancer therapy. The subtypes are currently recognized based onhistology. The aim of this work was to investigate an alternative approach for description of inherent molecular mechanisms resulting in its biological behavior. Genomic DNA was extracted fromformalin-fixed paraffin-embedded (FFPE) sections from 80 patients with histologically confirmed gastric cancer. A set of 70 genes was simultaneously examined by Multiplex Ligation-dependent Probe Amplification (MLPA) technique. The obtained gene amplification patterns were processed by hierarchical data clustering and evaluated in combination with clinical patientd data by multifactorial analysis. The overall success rate of DNA extraction from the gastric FFPE samples was at a level of
Czech name
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Czech description
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Project
<a href="/en/project/NT13640" target="_blank" >NT13640: Applicability of a panel of molecular markers in clinical management of advanced gastric cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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