The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26722445%3A_____%2F11%3A%230000651" target="_blank" >RIV/26722445:_____/11:#0000651 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež
Original language description
Interaction of epithermal neutrons with boron-10 (10B) leads to a damage of tumor tissue conferred (circumscribed) even soliatary cells. The nuclear reactors used for tumor therapy (Boron-Neutron-Capture-Therapy, BNCT) require individual tuning and monitoring by physical and biological methods. Here, were report effects of epithermal beam of the LVR-15 in Řež (7.8x 108n/cm2, 9 MW, 16.1 cGy/min) on the immature rat brain and C6 glioma culture, the model developed by us for this purpose (Mares et al. 1997, Burian et al. Kagawa). Irradiation of animals for 4 to 7 minutes induced the dose- and the cell differentiation degree- dependent apoptosis-like death in the cerebellum and forebrain, exceeding 2.1 times a gamma radiation equivalent. 3 days later, a dose inverse regeneration was evident in the cerebellum. In cultures irradiated for 30 to 45 min, the cells slowed-down cycling and cell death reaching a peak value at 72 to 96 h.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
BG - Nuclear, atomic and molecular physics, accelerators
OECD FORD branch
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Result continuities
Project
<a href="/en/project/FR-TI1%2F378" target="_blank" >FR-TI1/378: Application of neutron scattering in industry</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XX. Biologické dny : Kmenové buňky ? od regenerativní medicíny k nádorové biologii
ISBN
9788026008491
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
82-83
Publisher name
Československá biologická společnost a Lékařská fakulta UK v Plzni
Place of publication
Plzeň
Event location
Plzeň
Event date
Jan 1, 2011
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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