Negative prognostic significance of primary cilia, CD8 tumor infiltrating lymphocytes and PD1 cells expression in clear cell renal cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F19%3A00006947" target="_blank" >RIV/27283933:_____/19:00006947 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
čeština
Original language name
Negativní prognostický význam primární řasinky, CD8 tumor infiltrujících lymfocytů a PD1 exprese u renálního karcinomu
Original language description
Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8 tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8 TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1 cells were 50% in 5 patients. Intratumoral CD8 TIL were evaluable in all patients: negative in 1 patient, 50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (≥0.002) than in patients with lower frequency (25%) PD1 expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1 cells and CD8 TIL in patients with clear cell renal cancer.
Czech name
Negativní prognostický význam primární řasinky, CD8 tumor infiltrujících lymfocytů a PD1 exprese u renálního karcinomu
Czech description
Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8 tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8 TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1 cells were 50% in 5 patients. Intratumoral CD8 TIL were evaluable in all patients: negative in 1 patient, 50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (≥0.002) than in patients with lower frequency (25%) PD1 expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1 cells and CD8 TIL in patients with clear cell renal cancer.
Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů