Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537089" target="_blank" >RIV/60162694:G44__/19:00537089 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396020 RIV/00216208:11120/19:43918644 RIV/61989592:15110/19:73596398 RIV/00216224:14110/19:00108594 RIV/00064190:_____/19:N0000052

Result on the web

<a href="https://jbuon.com/archive/24-4-1644.pdf" target="_blank" >https://jbuon.com/archive/24-4-1644.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

Original language description

Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NV15-34678A" target="_blank" >NV15-34678A: Prognostic and predictive molecular factors in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of BUON

ISSN

1107-0625

e-ISSN

2241-6293

Volume of the periodical

24

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

1644-1651

UT code for WoS article

000481595900047

EID of the result in the Scopus database

2-s2.0-85071666686