A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F14%3AN0000006" target="_blank" >RIV/27661989:_____/14:N0000006 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/14:00076236 RIV/65269705:_____/14:00061256 RIV/00159816:_____/14:00061256

Result on the web

<a href="https://www.jgld.ro/jgld/index.php/jgld/article/view/1302" target="_blank" >https://www.jgld.ro/jgld/index.php/jgld/article/view/1302</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15403/jgld.2014.1121.232.vk1" target="_blank" >10.15403/jgld.2014.1121.232.vk1</a>

Result language

angličtina

Original language name

A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial

Original language description

Background & Aims: To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate (PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation. Methods: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy. Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure. The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale. Results: A total of 600 patients were enrolled, 88.2% were included in the analysis. Satisfactory bowel cleansing (Aronchick score 1 and 2) was significantly more frequent when a split dose was used irrespective of the solution type (81.6% PMC2/2, 87.3% PEG3/1 vs. 73.0% PEG4/0, p = 0.024). In single dose regimens, PMC performed better than PEG (82.6% vs. 73.0%). Single or split dose PMC preparations were comparable. A PMC based solution was generally better tolerated than PEG regardless of the regimen used (p <0.001). Nausea was reported mostly after the 4L PEG (32.8%, p < 0.001), incontinence after a split PMC dose (34.4%, p = 0.002), and bloating after the 4L PEG (38.0%, p < 0.001). There was no significant difference in the prevalence of vomiting. Conclusion: Colonic preparation with PMC yields similar results as a split PEG dose, regardless of whether PMC is administered in single or separate doses. PMC is better tolerated than any PEG-based preparation. A single 4L PEG the day before the colonoscopy is less appropriate for bowel cleansing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Gastrointestinal and Liver Diseases

ISSN

1841-8724

e-ISSN

1842-1121

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

RO - ROMANIA

Number of pages

6

Pages from-to

141-146

UT code for WoS article

000337333300007

EID of the result in the Scopus database

2-s2.0-84901910484