Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F15%3AN0000018" target="_blank" >RIV/27661989:_____/15:N0000018 - isvavai.cz</a>

Result on the web

<a href="https://publications.ersnet.org/content/erj/46/suppl59/oa2925" target="_blank" >https://publications.ersnet.org/content/erj/46/suppl59/oa2925</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2015.OA2925" target="_blank" >10.1183/13993003.congress-2015.OA2925</a>

Result language

angličtina

Original language name

Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD

Original language description

Background: The COPD has been recognized as a multiple-faced syndrome. Heterogeneity features of severe COPD patients still remains unknown. Aim: Systematic observation of the variety of symptoms and other clinical characteristics of severe airflow limitation subjects. Methods: The Czech Multicentre Research Database of COPD (Database) is a multicenter, observational, and prospective study of patients with post bronchodilator FEV1≤60%(NCT01923051). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Baseline data includes parameters used for identification of clinical phenotypes. Results: We have enrolled 488 patients from Aug13 to Dec14, 343 of them with complete set of parameters for phenotype assessment (250males,67.0 years,FEV143.0%,6.7% non-smokers). We found all GOLD categories (A 4.4%,B 14.9%,C 3.8%,D 73.8%) and six COPD phenotypes (bronchitic-b 75.5%,emphysematous-e 77.4%,exacerbators-ex 34.7%,bronchiectatic-be 28.4%,cachectic-ca 16.3%,ACOS-ac 4.2%) in our severe COPD cohort. Clinical assessment of phenotypes (without computer tomography) have high sensitivity (0.69-0.74) in majority of them (except be) and excellent specificity in all (0.71-0.99). Some phenotypes are significantly associated with more symptoms (fatigue in b,ex and dyspnea in ex,ca) greater value of BODE index (e,ex,ca), higher values of specific CAT items (b,ca,ex). Contrary e,ac,be COPD have not any CAT items predominance. Conclusion: 1st analysis of baseline data of the Database has confirmed the wide clinical distribution of COPD syndrome. Subjective evaluation by physicians achieves satisfactory sensitivity and specificity.

Czech name

—

Czech description

—

Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Volume of the periodical

46

Issue of the periodical within the volume

Supplement 59

Country of publishing house

CH - SWITZERLAND

Number of pages

1

Pages from-to

Meeting Abstract OA2925

UT code for WoS article

000451979400209

EID of the result in the Scopus database

—