COPD therapy based on clinical phenotypes: Baseline data from the Czech multicentre research database of COPD

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F15%3AN0000021" target="_blank" >RIV/27661989:_____/15:N0000021 - isvavai.cz</a>

Result on the web

<a href="https://publications.ersnet.org/content/erj/46/suppl59/pa1058" target="_blank" >https://publications.ersnet.org/content/erj/46/suppl59/pa1058</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2015.PA1058" target="_blank" >10.1183/13993003.congress-2015.PA1058</a>

Result language

angličtina

Original language name

COPD therapy based on clinical phenotypes: Baseline data from the Czech multicentre research database of COPD

Original language description

Background: Several sets of guidelines, statements and strategies for managing and therapy of COPD exist around the world. Czech national COPD guideline defines 6 clinically relevant phenotypes and recommends therapy of COPD based on clinical phenotypes. Aim: The analysis of COPD therapy based on clinical phenotypes in the real practice. Methods: The Czech Multicentre Research Database of COPD (Database) is a multicenter, observational, and prospective study of patients with COPD and post bronchodilator FEV1≤60% (NCT01923051). Baseline data include the parameters used for identification of clinical phenotypes, and information about COPD therapy of each subject. Therapy strategies were analysed in accordance to clinical phenotypes and GOLD categories. Results: A total of 488 patients were enrolled into the Database. We found all six COPD phenotypes according to Czech COPD Guideline – bronchitic (bc) 75.5%, emphysematous (em) 77.4%, frequent exacerbators (ex) 34.7%, bronchiectatic (be) 28.4%, cachectic (ca) 16.3%, ACOS (acos) 4.2%. We found differences in treatment between phenotypes, including significantly higher use of mucoactive drugs in bc, ex, roflumilast in bc, ex, ICS+LABA in acos, long term antibiotic therapy in be, bronchoscopic lung volume reduction in em. There were also differences between COPD treatment based on clinical phenotypes and COPD treatment based on GOLD categories. Conclusion: 1st analysis of baseline data of the Database has confirmed the usefulness of phenotype-based therapy of COPD. Supported by IGA MZ CR NT/13560.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30203 - Respiratory systems

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Volume of the periodical

46

Issue of the periodical within the volume

Supplement 59

Country of publishing house

CH - SWITZERLAND

Number of pages

1

Pages from-to

PA1058

UT code for WoS article

000451979401167

EID of the result in the Scopus database

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