Implementation of the GOLD 2017 disease classification in a real-life COPD cohort

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F18%3AN0000020" target="_blank" >RIV/27661989:_____/18:N0000020 - isvavai.cz</a>

Result on the web

<a href="https://publications.ersnet.org/content/erj/52/suppl62/pa3858" target="_blank" >https://publications.ersnet.org/content/erj/52/suppl62/pa3858</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2018.PA3858" target="_blank" >10.1183/13993003.congress-2018.PA3858</a>

Result language

angličtina

Original language name

Implementation of the GOLD 2017 disease classification in a real-life COPD cohort

Original language description

Introduction: During the last decade, the GOLD classification of COPD underwent notable evolution. There is limited evidence how the latest classification approach affected the distribution of COPD patients accross A-D groups. Our aim was to assess predictive value of the last 3 GOLD classification systems (I-IV (pre 2011), A-D (2011-2016) and A-D (2017-present)) in relation to long-term mortality of COPD patients from the CMRD cohort. Methods: We used the prospective data of 784 patients from the CMRD cohort (at 4-year follow-up). Kaplan-Meier survival analysis was performed for the 3 above mentioned GOLD classification systems. Results: Application of the GOLD I-IV system showed gradual and significant increase in 4-year mortality across the stages (GOLD II 18.7%, GOLD III 28.5%, GOLD IV 38.7%) (p=0.001). Application of the GOLD A-D system (2011-2016) showed group D being the most populous category with 523 patients (66.7%) and highest rate of 4-year mortality (30%). Group C patients had lower mortality (17.9%) than group B patients (18.7%) (p=0.01). Finally, using the GOLD A-D 2017 classification approach resulted in major shifts of patients accross groups A-D with group B being most abundant (52.5%). Similarly, mortality in group B patients was significantly higher (25%) than in group C (23.1%). Conclusion: Our results show that the current GOLD classification possesses gradual predictive value for long-term mortality. Another important finding is that the adaptation of the 2017 GOLD Update resulted in shift from group D to B of ca 40% of former group D COPD patients. In consequence, this might result in significant treatment reduction (with possible harmful consequences)in a real-life setting.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30203 - Respiratory systems

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Volume of the periodical

52

Issue of the periodical within the volume

Supplement 62

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

PA3858

UT code for WoS article

000455567104496

EID of the result in the Scopus database

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