Estimated glomerular filtration rate in patients overdosed with gentamicin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F20%3AN0000004" target="_blank" >RIV/27661989:_____/20:N0000004 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/20:A21025ZP
Result on the web
<a href="https://www.degruyterbrill.com/document/doi/10.1515/labmed-2019-0124/html" target="_blank" >https://www.degruyterbrill.com/document/doi/10.1515/labmed-2019-0124/html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/labmed-2019-0124" target="_blank" >10.1515/labmed-2019-0124</a>
Alternative languages
Result language
angličtina
Original language name
Estimated glomerular filtration rate in patients overdosed with gentamicin
Original language description
Background: The aim of this study was to compare the estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcrea) and cystatin C (eGFRcys) in patients with elevated serum trough levels of gentamicin before the next planned dose during treatment in the intensive care unit (ICU). Methods: This was a retrospective observational study. Patients who stayed in an ICU, received a once-daily dose of gentamicin, and who had results from all serum gentamicin trough levels, eGFRcrea and eGFRcys analyses were included in the study. Overdosed patients were defined as those with serum gentamicin trough levels above 1 mg/L before the next dose. Gentamicin was measured by a particle-enhanced turbidimetric immunoassay (PETIA). Creatinine and cystatin C were measured by standardized methods. Results: The median age (range) was lower in all patients with gentamicin concentration measurements than in overdosed patients (67 [19-96] vs. 75 [48-99] years, respectively; p < 0.0001). The median interquartile range (IQR) of the eGFRcrea was higher than that of the eGFRcys in overdosed patients (60 [44-79] mL/min/1.73 m(2) vs. 41 [29-58] mL/min/1.73 m2, respectively; p < 0.0001). The median IQR of the eGFRcrea was higher than that of the eGFRcys in controls (87 [78-98] mL/min/1.73 m(2) vs. 66 [54-93] mL/min/1.73 m(2), respectively; p < 0.0001). Conclusions: Overdosed patients had both a lower eGFRcrea and eGFRcys than controls. Elderly patients are the most commonly overdosed patients. We recommend measuring cystatin C and calculating the eGFRcys and combined equation (eGFRcrea + cys) in ICU patients over 65 years of age, which would enable improved gentamicin dosage adjustments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Laboratory Medicine
ISSN
2567-9430
e-ISSN
2567-9449
Volume of the periodical
44
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
35-39
UT code for WoS article
000512769200007
EID of the result in the Scopus database
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