Cystatin C may be better than creatinine for digoxin dosing in older adults with atrial fibrillation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F20%3AN0000005" target="_blank" >RIV/27661989:_____/20:N0000005 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/20:A21025ZB
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.23427" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.23427</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcla.23427" target="_blank" >10.1002/jcla.23427</a>
Alternative languages
Result language
angličtina
Original language name
Cystatin C may be better than creatinine for digoxin dosing in older adults with atrial fibrillation
Original language description
Background Patients taking digoxin are older with high probability of having low muscle mass, and current clinical practice in digoxin dosing relies only on estimated glomerular filtration rate from serum creatinine (eGFRcrea). The aim of the study is to compare eGFRcrea and estimated glomerular filtration rate from serum cystatin C (eGFRcys) in older adult patients with atrial fibrillation (AF) overdosed with digoxin. Methods A total of 80 consecutive patients overdosed with digoxin and 33 controls with AF from Department of Internal Medicine were included in the prospective observational study. The median of age of participants was 81 years in both the overdosed and the control group. The eGFRs were calculated using The Chronic Kidney Disease Epidemiology (CKD- EPI) equations using standardized methods for serum creatinine and cystatin C measurement. Results The median (IQR) of eGFRcrea was higher than that of eGFRcys (45 mL/min/1.73 m(2)(35-59) vs 30 (21-38), respectively;P < .0001) in overdosed patients. The median (IQR) of eGFRcrea was higher than that of eGFRcys (61 mL/min/1.73 m(2)(49-72) vs 40 (30-56), respectively;P < .0001) in control group of patients. Serum predose digoxin concentration in overdosed patients was inversely associated with eGFRcys (rho = -0.26,P < .05). Conclusion Physicians should consider GFR when changing digoxin dosing. eGFRcys was lower in both the overdosed and the control group. eGFRcys would lead to lower digoxin doses and thus prevent overdose.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Laboratory Analysis
ISSN
0887-8013
e-ISSN
1098-2825
Volume of the periodical
34
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
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UT code for WoS article
000540617200001
EID of the result in the Scopus database
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