The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F23%3A10003392" target="_blank" >RIV/27661989:_____/23:10003392 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/ecco-jcc/article/17/Supplement_1/i1023/7010319" target="_blank" >https://academic.oup.com/ecco-jcc/article/17/Supplement_1/i1023/7010319</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ecco-jcc/jjac190.1041" target="_blank" >10.1093/ecco-jcc/jjac190.1041</a>
Alternative languages
Result language
angličtina
Original language name
The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin
Original language description
This study evaluated changes in the faecal microbiome and metabolome after anti‑TNFα therapy in children with Crohn’s disease (CD) and compared them with children diagnosed with juvenile idiopathic arthritis (JIA), a condition that rarely affects the intestine. A total of 530 stool samples were analysed using 16S rRNA V4 region sequencing and ¹H NMR metabolomics. Anti‑TNFα therapy in CD led to a significant reduction in faecal calprotectin and induced specific microbial and metabolite changes that were not observed in JIA. In CD, the abundances of Blautia, Ruminococcus, Intestinibacter and Erysipelatoclostridium increased, whereas Allistipes decreased. Among metabolites, glucose and glycerol increased, while isoleucine and uracil decreased. The findings indicate that the microbiome shifts following anti‑TNFα therapy are secondary to the improvement of intestinal inflammation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Crohn's and Colitis
ISSN
1873-9946
e-ISSN
1876-4479
Volume of the periodical
17
Issue of the periodical within the volume
Supplement 1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
1023-1024
UT code for WoS article
000960367602135
EID of the result in the Scopus database
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