In vitro identification of novel acetylcholinesterase reactivators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F09%3A00004898" target="_blank" >RIV/44555601:13440/09:00004898 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/09:00002214
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro identification of novel acetylcholinesterase reactivators
Original language description
Organophosphate compounds exert toxicity primarily by virtue of acetylcholinesterase (AChE) inactivation at the nerve synapses and neuromuscular junction, leading to accumulation of acetylcholine (ACh). Therefore, treatment of organophosphate poisoningsgenerally relies upon AChE reactivators, anticholinergic drugs, and anticonvulsants. Although there are many structurally different AChE reactivators, only five of them are used clinically. Unfortunately, there is not a single compound that can reactivate inhibited AChE against all nerve agents, or a so-called broad spectrum reactivator. Due to this limitation, the quest for new derivatives continues. For newly synthesized derivatives, in vitro and in vivo evaluation of their reactivation efficacy is ofthe utmost importance in AChE reactivators' development. This review article presents literature on the most promising novel AChE reactivators. Furthermore, in vitro and in vivo techniques used for their evaluation are also discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
AQ - Safety and health protection, safety in operating machinery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxin Reviews
ISSN
1556-9543
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000273048000002
EID of the result in the Scopus database
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