Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F14%3A43885156" target="_blank" >RIV/44555601:13440/14:43885156 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c3ra45408h" target="_blank" >http://dx.doi.org/10.1039/c3ra45408h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c3ra45408h" target="_blank" >10.1039/c3ra45408h</a>
Alternative languages
Result language
angličtina
Original language name
Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
Original language description
Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, andother with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimersfunctionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RSC Advances
ISSN
2046-2069
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1256-1265
UT code for WoS article
000327868400035
EID of the result in the Scopus database
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