An Evaluation of the Information Technology of Gene Expression Profiles Processing Stability for Different Levels of Noise Components
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F18%3A43894141" target="_blank" >RIV/44555601:13440/18:43894141 - isvavai.cz</a>
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=3&SID=D4oY3FX1SDm3LATgKuu&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=3&SID=D4oY3FX1SDm3LATgKuu&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/data3040048" target="_blank" >10.3390/data3040048</a>
Alternative languages
Result language
angličtina
Original language name
An Evaluation of the Information Technology of Gene Expression Profiles Processing Stability for Different Levels of Noise Components
Original language description
This paper presents the results of research concerning the evaluation of stability of information technology of gene expression profiles processing with the use of gene expression profiles, which contain different levels of noise components. The information technology is presented as a structural block-chart, which contains all stages of the studied data processing. The hybrid model of objective clustering based on the SOTA algorithm and the technology of gene regulatory networks reconstruction have been investigated to evaluate the stability to the level of the noise components. The results of the simulation have shown that the hybrid model of the objective clustering has high level of stability to noise components and vice versa, the technology of gene regulatory networks reconstruction is rather sensitive to the level of noise component. The obtained results indicate the importance of gene expression profiles preprocessing at the early stage of the gene regulatory network reconstruction in order to remove background noise and non-informative genes in terms of the used criteria.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Data
ISSN
2306-5729
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1-15
UT code for WoS article
000454696600011
EID of the result in the Scopus database
2-s2.0-85070926550