Synthesis of bow-tie carbosilane dendrimers and their HIV antiviral capacity: A comparison of the dendritic topology on the biological process

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F19%3A43894892" target="_blank" >RIV/44555601:13440/19:43894892 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0014305719310948?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719310948?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2019.07.034" target="_blank" >10.1016/j.eurpolymj.2019.07.034</a>

Result language
angličtina
Original language name
Synthesis of bow-tie carbosilane dendrimers and their HIV antiviral capacity: A comparison of the dendritic topology on the biological process
Original language description
A simple and versatile synthetic approach was designed for the formation of sulfonate-terminated bow-tie carbosilane dendrimers with different cores as hydroquinone moiety, triazol ring or carbamate group. These systems were designed to compare biological and biomedical properties attending to the shape or topology of the carbosilane dendritic systems: spherical, dendrons and bow-tie architectures. Biocompatibility and HIV antiviral activity were measured in TZM.bl cells as human epithelial cell line. Sulfonate groups at the periphery of the dendritic systems were selected due to the ability of previously reported anionic dendrimers to interact with important receptor in viral infection. Finally, experimental results were compared with theoretical data showing a clear relationship between topology and biological activity, being a parameter to consider for exploring biomedical applications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30309 - Tropical medicine

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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