Preparation of PSEBS membranes bearing (S)-(MINUS SIGN )-methylbenzylamine as chiral selector

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F20%3A43894889" target="_blank" >RIV/44555601:13440/20:43894889 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0014305719311930#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719311930#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2019.109381" target="_blank" >10.1016/j.eurpolymj.2019.109381</a>

Result language
angličtina
Original language name
Preparation of PSEBS membranes bearing (S)-(MINUS SIGN )-methylbenzylamine as chiral selector
Original language description
Nowadays, there is a strong need for replacement of racemates by enantiomerically pure drugs. Enantioseparation on polymer membranes seems to be one of the promising and economically feasible technologies for this purpose. As a material for membrane construction, linear polymer molecules bearing covalently bonded chiral selectors are very promising according to recent reports. A membrane formed from chloromethylated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (PSEBS) was cast and subsequently functionalized with a chiral selector (S)-(MINUS SIGN )-?-methylbenzylamine. In preferential sorption experiments with racemic tryptophan and ibuprofen, the prepared membrane exhibited a higher affinity to l-tryptophan and (R)-(MINUS SIGN )-ibuprofen than to corresponding enantiomers. The significant change in peak ratio from 48:52 to 60:40 (d-tryptophan:l-tryptophan) was observed. This indicates the high potential of the covalently bonded (S)-(MINUS SIGN )-?-methylbenzylamine selector for the fabrication of membranes selective towards chiral acids and ampholytes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GA17-00089S" target="_blank" >GA17-00089S: Separation of Racemic Mixtures by Membrane Processes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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