Centrosomal and acentrosomal microtubule nucleation during neuronal development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F25%3A43899078" target="_blank" >RIV/44555601:13440/25:43899078 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0959438825000479" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0959438825000479</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.conb.2025.103016" target="_blank" >10.1016/j.conb.2025.103016</a>
Alternative languages
Result language
angličtina
Original language name
Centrosomal and acentrosomal microtubule nucleation during neuronal development
Original language description
Neurons rely on the microtubule cytoskeleton to create and maintain their sophisticated cellular architectures. Advances in cryogenic electron microscopy, expansion microscopy, live imaging, and gene editing have enabled novel insights into mechanisms of centrosomal and acentrosomal microtubule nucleation, the key process generating new microtubules. This has paved the way for the functional dissection of distinct microtubule networks that regulate various processes during neuronal development, including neuronal delamination, polarization, migration, maturation, and synapse function. We review recent progress in understanding the molecular concepts of microtubule nucleation, how these concepts underlie neurodevelopmental processes, and pinpoint the open questions. Since microtubules play a pivotal role in axon regeneration within the adult central nervous system, understanding the processes of microtubule nucleation could inform strategies to enhance the regenerative capabilities of neurons in the future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Neurobiology
ISSN
0959-4388
e-ISSN
1873-6882
Volume of the periodical
2025
Issue of the periodical within the volume
92
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
"nestrankovano"
UT code for WoS article
001459225900001
EID of the result in the Scopus database
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