Radiolabeling of antibody for epitope of human carbonic anhydrase IX (IgG M75) by 61Cu and 64Cu and its biological testing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46356088%3A_____%2F15%3A%230001712" target="_blank" >RIV/46356088:_____/15:#0001712 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Radiolabeling of antibody for epitope of human carbonic anhydrase IX (IgG M75) by 61Cu and 64Cu and its biological testing

Original language description

The subject of the work was conjugating antibody IgG M75 for epitope human carbonic anhydrase IX with non-commercial new chelator denoted as phospinate specific for copper isotopes. The labelling resulted in the product of high specific activity (1.0 and 7.4 MBq/μg, respectively) and of high radiochemical purity (> 95 %). The labelled molecule has considerable potential as a radioimmunopharmaceutical suitable for imaging of tumors expressing carbonic anhydrase IX by positron emission tomography (PET).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

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Project

<a href="/en/project/TA02010797" target="_blank" >TA02010797: Labelling of recombinant antibody fragments with use of microfluidic systems</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Nuclear Medicin and Molecular Imaging

ISSN

1619-7070

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

S1

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

465-466

UT code for WoS article

000363013202432

EID of the result in the Scopus database

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