Radiolabeling of the antibody IgG M75 for epitope of human carbonic anhydrase IX by Cu-61 and Cu-64 and its biological testing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00501136" target="_blank" >RIV/61389005:_____/19:00501136 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/19:00501136 RIV/00216208:11160/19:10393716 RIV/00216208:11310/19:10393716 RIV/46356088:_____/19:N0000021

Result on the web

<a href="https://doi.org/10.1016/j.apradiso.2018.10.021" target="_blank" >https://doi.org/10.1016/j.apradiso.2018.10.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apradiso.2018.10.021" target="_blank" >10.1016/j.apradiso.2018.10.021</a>

Result language

angličtina

Original language name

Radiolabeling of the antibody IgG M75 for epitope of human carbonic anhydrase IX by Cu-61 and Cu-64 and its biological testing

Original language description

Human carbonic anhydrase IX is a membrane enzyme that is significantly expressed in some types of cancer cells, while copper radioisotopes offer wide range of diagnostic, therapeutic and theranostic properties. The work was focused on a new approach to the labelling of antibody IgG M75 for epitope human carbonic anhydrase IX with copper radioisotopes Cu-61 and Cu-64 and its in vivo testing in mice with inoculated colorectal cancer. Monoclonal antibody IgG M75 for epitope human carbonic anhydrase IX was successfully conjugated with copper-specific chelator 'phosphinate' and labelled with Cu-61 and Cu-64 The obtained molecule has considerable potential as a radioimmuno pharmaceutical suitable for imaging of tumours expressing carbonic anhydrase IX by positron emission tomography (PET).

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Radiation and Isotopes

ISSN

0969-8043

e-ISSN

—

Volume of the periodical

143

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

87-97

UT code for WoS article

000453338900014

EID of the result in the Scopus database

2-s2.0-85055754615