Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F09%3A%230001095" target="_blank" >RIV/46747885:24210/09:#0001095 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/09:00002113 RIV/00216208:11150/09:00208803

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX

Original language description

Differences between acetylcholinesterase (AChE) inhibition in the brain structures following VX and RVX exposure are not known as well as information on the possible correlation of biochemical and histochemical methods detecting AChE activity. Therefore,inhibition of AChE in different brain parts detected by histochemical and biochemical techniques was compared in rats intoxicated with VX and RVX. AChE activities in defined brain regions 30 min after treating rats with VX and Russian VX intramuscularly(1.0 x LD50) were determined by using biochemical and histochemical methods. AChE inhibition was less expressed for RVX, in comparison with VX. Frontal cortex and pontomedullar areas containing ncl. reticularis has been found as the most sensitive areasfor the action of VX. For RVX, these structures were determined to be frontal cortex, dorsal septum, and hippocampus, respectively.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/OPUOFVZ200603" target="_blank" >OPUOFVZ200603: A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

DRUG AND CHEMICAL TOXICOLOGY

ISSN

0148-0545

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

2009

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000266590400001

EID of the result in the Scopus database

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