In vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001306" target="_blank" >RIV/60162694:G44__/05:00001306 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/05:00007145
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
In vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX
Original language description
Organophosphorus compounds, especially nerve agents, inhibit enzyme acetylcholinesterase (AChE; EC 3.1.1.7) in an irreversible manner. Atropine plus an oxime reactivator are used as an effective treatment of organophosphate poisoning. In this work, we have evaluated reactivation potency of twenty reactivators of different chemical structures in reactivation of VX-inhibited AChE. Rat brain AChE homogenate was used as the appropriate source of the enzyme. According to our results, trimedoxime seems to bethe most potent reactivator of VX-inhibited AChE at the concentration 10-3 M.
Czech name
In vitro hledání nového potenciálního reaktivátoru acetylchlinesterázy inhibované látkou VX
Czech description
In vitro hledání nového potenciálního reaktivátoru acetylchlinesterázy inhibované látkou VX.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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