Structure-Activity Relationship for the Reactivators of Acetylcholinesterase Inhibited by Nerve Agent VX

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F13%3A50001683" target="_blank" >RIV/62690094:18470/13:50001683 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/13:43874603
Result on the web
<a href="http://www.benthamscience.com/contents.php?in=111593&m=August&y=2013" target="_blank" >http://www.benthamscience.com/contents.php?in=111593&m=August&y=2013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1573406411309050008" target="_blank" >10.2174/1573406411309050008</a>

Result language
angličtina
Original language name
Structure-Activity Relationship for the Reactivators of Acetylcholinesterase Inhibited by Nerve Agent VX
Original language description
Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents. None fromthe known AChE reactivators is able to reactivate AChE inhibited by all kinds of nerve agents. In this work, reactivation potency of seventeen structurally different AChE reactivators was tested in vitro and subsequently, relationship between their chemical structure and biological activity was outlined. VX was chosen as appropriate member of the nerve agent family.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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