TRISOXIME - a Bulky Trisquaternary Reactivator of Acetylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1701LLI" target="_blank" >RIV/61988987:17110/16:A1701LLI - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/16:10323694 RIV/60162694:G44__/16:43875591 RIV/62690094:18470/16:50004679
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
TRISOXIME - a Bulky Trisquaternary Reactivator of Acetylcholinesterase
Original language description
Structure of acetylcholinesterase (AChE) reactivators influences their reactivation activity. Monoquaternary or bisquaternary reactivators are generally used for this purpose. In this work, there is discussed in vitro activity of trisquaternary AChE reactivator - Trisoxime (K388). Its reactivation activity is tested on the AChE inhibited by selected nerve agents - tabun, sarin, cyclosarin, soman, VX, Russian VX and diisopropyl fluorophosphates (DFP). As a result, only AChE inhibited by three nerve agents (VX, Russian VX and DFP) was satisfactorily reactivated at tested oxime concentrations (10(-5) M and 10(-3) M). This relatively poor reactivation potency was probably caused by the bulky spherical structure of tested oxime. Although results obtained in this study are not favorable, they are showing that the addition of one more quaternary ring to the reactivator's molecule is not the right way to improve its reactivation potency.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LETTERS IN DRUG DESIGN & DISCOVERY
ISSN
1570-1808
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
5
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
4
Pages from-to
372-375
UT code for WoS article
000374883700003
EID of the result in the Scopus database
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