Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F15%3A86096523" target="_blank" >RIV/61989100:27240/15:86096523 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875423 RIV/62690094:18450/15:50003718 RIV/62690094:18470/15:50003718 RIV/00179906:_____/15:10301850
Result on the web
<a href="http://dx.doi.org/10.2174/1573406411666150407154204" target="_blank" >http://dx.doi.org/10.2174/1573406411666150407154204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1573406411666150407154204" target="_blank" >10.2174/1573406411666150407154204</a>
Alternative languages
Result language
angličtina
Original language name
Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
Original language description
Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE). Although it was originally developed for treatment of tabun intoxications, it is able to reactivate cholinesterases inhibited by othernerve agents. This study is aimed at the evaluation of its potency in vitro against other nerve agents. For this purpose, sarin, tabun, cyclosarin, soman, VX, Russian VX and DFP were selected as members of the nerve agent family to check its universality. At high concentrations (10(-3) M), oxime K203 reached promising reactivation activity. At low concentrations, relevant for human use (10(-5) M), promising reactivation potency was obtained only with tabun. In conclusion, oxime K203 reactivates other nerve agents-inhibited cholinesterases, however its broad-spectrum reactivation is limited at high, for human not attainable, concentrations only.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal Chemistry
ISSN
1573-4064
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
7
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
4
Pages from-to
683-686
UT code for WoS article
000361825400011
EID of the result in the Scopus database
2-s2.0-84947812206