BIOMARKERS OF OXIDATIVE STRESS AND INFLAMMATION IN RESEARCHERS EXPOSED TO NANOPARTICLES BY INHALATION DURING THE HANDLING OF NANOCOMPOSITES

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F19%3A00008852" target="_blank" >RIV/46747885:24210/19:00008852 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/19:10409649 RIV/00216208:11110/19:10409649

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

BIOMARKERS OF OXIDATIVE STRESS AND INFLAMMATION IN RESEARCHERS EXPOSED TO NANOPARTICLES BY INHALATION DURING THE HANDLING OF NANOCOMPOSITES

Original language description

At present, little is known about the health effects in the workers processing nanocomposites. In our study, 20 researchers (41.8 /- 11.4 y/o), handling nanocomposites for 17.8 /- 10.0 years were examined pre-shift and post-shift, together with 21 controls (42.7 /- 11.5 y/o). Biomarkers of oxidative stress derived from lipids, nucleic acids, proteins and markers of inflammation were analyzed in the exhaled breath condensate (EBC). Aerosol exposure was monitored during three nanoparticle generation operations: smelting, welding and nanocomposite machining. Mass concentrations during these operations ranged from 0.120 to 1.840 mg/m(3), and median particle number concentrations from 4.8x10(4) to 5.4x10(5) particles/cm(3). Nanoparticles accounted for 40 to 95 % of particles, with Fe and Mn prevailing. Significant elevations were already seen in most oxidative stress markers and in several inflammation markers in the pre-shift samples relative to the controls. Significant associations were found between working in nanocomposite synthesis and the majority of EBC biomarkers. Chronic bronchitis was more frequent in researchers. A minor, but significant post-shift decrease of lung function parameters was found. We conclude that workers in nanocomposite synthesis may be at risk of developing airway disorders with time. From all the markers analyzed in EBC, the following markers were most robust and could be recommended for preventive examinations: 8-hydroxy-2-deoxyguanosine (8-OHdG) and 5-hydroxymethyl uracil (5-OHMeU) from nucleic acids; o-tyrosine (o-Tyr) and 3-nitrotyrosine (3-NOTyr) from proteins; and malondialdehyde and aldehydes C6-C13 from lipids. Among the markers of inflammation, tumor necrosis factor (TNF) and leukotriene B4 appeared to be the most useful.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON Conference Proceedings - International Conference on Nanomaterials

ISBN

978-80-87294-89-5

ISSN

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e-ISSN

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Number of pages

6

Pages from-to

531-536

Publisher name

TANGER LTD, KELTICKOVA 62, SLEZSKA, OSTRAVA 710 00, CZECH REPUBLIC

Place of publication

Czech Republic

Event location

Brno, CZECH REPUBLIC

Event date

Jan 1, 2018

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000513131900092