Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F22%3A00009524" target="_blank" >RIV/46747885:24220/22:00009524 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24530/22:00009524 RIV/00023001:_____/22:00082636 RIV/00216208:11110/22:10442799 RIV/00216224:14740/22:00128771
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/35246950/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/35246950/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202100523" target="_blank" >10.1002/mabi.202100523</a>

Result language
angličtina
Original language name
Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging
Original language description
31 P-magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus-containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal-free 31 P-MR probe based on phosphorus-containing polymeric zwitterion. The developed probe (pTMPC) is a well-defined water-soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high-intensity 31 P-MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive 31 P-MR sensor of pathological conditions in vivo because it undergoes oxidation-induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable 1 H and 31 P T1 /T2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of 31 P-MR spectroscopy and imaging.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/NU20-08-00095" target="_blank" >NU20-08-00095: New paradigm for functional contrast agent for 31P magnetic resonance imaging</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2022
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Similar results(10)