Phosphorus-containing polymeric zwitterion: a pioneering bioresponsive probe for 31P-magnetic resonance imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00557336" target="_blank" >RIV/61389013:_____/22:00557336 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/22:00557336 RIV/44555601:13440/22:43896880
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/mabi.202100523" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mabi.202100523</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202100523" target="_blank" >10.1002/mabi.202100523</a>
Alternative languages
Result language
angličtina
Original language name
Phosphorus-containing polymeric zwitterion: a pioneering bioresponsive probe for 31P-magnetic resonance imaging
Original language description
31P-magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus-containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal-free 31P-MR probe based on phosphorus-containing polymeric zwitterion. The developed probe (pTMPC) is a well-defined water-soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high-intensity 31P-MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive 31P-MR sensor of pathological conditions in vivo because it undergoes oxidation-induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable 1H and 31P T1/T2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of 31P-MR spectroscopy and imaging.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
1616-5195
Volume of the periodical
22
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
2100523
UT code for WoS article
000766947400001
EID of the result in the Scopus database
2-s2.0-85126066378