Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00004041" target="_blank" >RIV/46747885:24410/16:00004041 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pat.3875" target="_blank" >10.1002/pat.3875</a>

Result language
angličtina
Original language name
Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters
Original language description
Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of materials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with inner diameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(l-lactide) caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types in each layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechanically. Obtained results of mechanical performance were discussed according to the used polymer-type composition, fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaffolds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable polymers in different combinations in each layer causes notable differences in fiber morphology and mechanical performance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pressures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracellular matrix of tunica media in native vessels.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JJ - Other materials
OECD FORD branch
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Project
<a href="/en/project/NV15-29241A" target="_blank" >NV15-29241A: Nanofibrous Biodegradable Small-Diameter Vascular Bypass Graft</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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