Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F17%3A00000040" target="_blank" >RIV/46747885:24410/17:00000040 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pat.3875" target="_blank" >10.1002/pat.3875</a>

Result language
angličtina
Original language name
Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters
Original language description
Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of mate-rials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with innerdiameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(L-lactide)caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types ineach layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechani-cally. Obtained results of mechanical performance were discussed according to the used polymer-type composition,fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaf-folds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable poly-mers in different combinations in each layer causes notable differences in fiber morphology and mechanicalperformance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pres-sures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracel-lular matrix of tunica media in native vessels.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)

Project
<a href="/en/project/NV15-29241A" target="_blank" >NV15-29241A: Nanofibrous Biodegradable Small-Diameter Vascular Bypass Graft</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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