Electrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid artery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F18%3A00005559" target="_blank" >RIV/46747885:24410/18:00005559 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24620/18:00005559
Result on the web
<a href="http://iopscience.iop.org/article/10.1088/1748-605X/aade9d" target="_blank" >http://iopscience.iop.org/article/10.1088/1748-605X/aade9d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1748-605X/aade9d" target="_blank" >10.1088/1748-605X/aade9d</a>

Result language
angličtina
Original language name
Electrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid artery
Original language description
The study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-computed tomography analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 μm and fiber diameters of 5.58 ± 0.10 μm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after six months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed. However, the degradation rate was found to be accelerated in the rabbit animal model. The study was conducted under conditions that reflected the clinical requirements—the prostheses were sutured in the end-to-side fashion and the long-term end point of prosthesis healing was assessed. The regeneration of the vessel wall in terms of endothelialization, smooth cell infiltration and the presence of collagen fibers was observed after six months in vivo. A part of the grafts failed due to the rapid degradation rate of the PLCL copolymer.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/ED3.1.00%2F14.0308" target="_blank" >ED3.1.00/14.0308: Nanofiber materials for tissue engineering</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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