An assessment of blood vessel remodeling of nanofibrous poly(ε‐caprolactone) vascular grafts in a rat animal model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F23%3A00010625" target="_blank" >RIV/46747885:24410/23:00010625 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24510/23:00010625 RIV/00216208:11140/23:10456162

Result on the web

<a href="https://www.mdpi.com/2079-4983/14/2/88" target="_blank" >https://www.mdpi.com/2079-4983/14/2/88</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jfb14020088" target="_blank" >10.3390/jfb14020088</a>

Result language

angličtina

Original language name

An assessment of blood vessel remodeling of nanofibrous poly(ε‐caprolactone) vascular grafts in a rat animal model

Original language description

The development of an ideal vascular prosthesis represents an important challenge in terms of the treatment of cardiovascular diseases with respect to which new materials are being considered that have produced promising results following testing in animal models. This study focuses on nanofibrous polycaprolactone-based grafts assessed by means of histological techniques 10 days and 6 months following suturing as a replacement for the rat aorta. A novel stereological approach for the assessment of cellular distribution within the graft thickness was developed. The cellularization of the thickness of the graft was found to be homogeneous after 10 days and to have changed after 6 months, at which time the majority of cells was discovered in the inner layer where the regeneration of the vessel wall was found to have occurred. Six months following implantation, the endothelialization of the graft lumen was complete, and no vasa vasorum were found to be present. Newly formed tissue resembling native elastic arteries with concentric layers composed of smooth muscle cells, collagen, and elastin was found in the implanted polycaprolactone-based grafts. Moreover, the inner layer of the graft was seen to have developed structural similarities to the regular aortic wall. The grafts appeared to be well tolerated, and no severe adverse reaction was recorded with the exception of one case of cartilaginous metaplasia close to the junctional suture.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF FUNCTIONAL BIOMATERIALS

ISSN

2079-4983

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

1-18

UT code for WoS article

000938610300001

EID of the result in the Scopus database

2-s2.0-85148905354