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Highly antibacterial electrospun double-layer mats for preventing secondary wound damage and promoting unidirectional water conduction in wound dressings

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F23%3A00011975" target="_blank" >RIV/46747885:24410/23:00011975 - isvavai.cz</a>

  • Result on the web

    <a href="https://api.elsevier.com/content/article/PII:S1226086X2200689X?httpAccept=text/xml" target="_blank" >https://api.elsevier.com/content/article/PII:S1226086X2200689X?httpAccept=text/xml</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jiec.2022.11.063" target="_blank" >10.1016/j.jiec.2022.11.063</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Highly antibacterial electrospun double-layer mats for preventing secondary wound damage and promoting unidirectional water conduction in wound dressings

  • Original language description

    The efficient absorption of wound exudate and the prevention of soft tissue infection are major concerns in wound repair. Good antibacterial agents and unique wound dressing structures can effectively reduce wound infection, thereby accelerating wound healing. In some double-layer asymmetric wound dressings, antimicrobial agents are incorporated in the hydrophilic layer, and only a small fraction of the antimicrobial agent penetrates the hydrophobic fibre layer towards the interior of the wound. Therefore, in this study, we chose curcumin (Cur.)/cellulose acetate (CA) as the hydrophobic inner layer. Not only does this effectively allow Cur. to make contact with the lining of the wound but it also prevents the wound from sticking. However, the mechanical properties of a single CA/Cur. layer are not ideal. Using polyacrylonitrile as the outer hydrophilic substrate improves the fibre mat mechanical properties. In addition, to further improve the hydrophilicity, the water contact angle was reduced by introducing a hydrophilic group (2-hydroxypropyl-β-cyclodextrin, β-CD) and changing the fibre roughness (nano-TiO2). Thus, wound dressings with high biocompatibility, excellent antibacterial properties, and unidirectional water conduction were constructed for preventing secondary wound damage. In terms of performance, it took 40 minutes for water to enter the hydrophilic fibre layer from the hydrophobic fibre layer (the water contact angle decreased from 121.24° to 85.42°), and it took 25 minutes for water to completely enter the fibre mats (the water contact angle decreased from 85.42°-0°), which is effective for draining wound exudate. In terms of antibacterial properties, the antibacterial rates of Cur. (8 wt%) against Escherichia coli and Staphylococcus aureus were 82.4% and 92.57%, respectively. The Cur./CA@PAN/β-CD/TiO2 bilayer asymmetric nanofibrous mats mimic the semipermeability of the extracellular matrix (ECM) and have high biocompatibility, which is effective for preventing secondary wound damage. It can be used as a low-cost, high-performance wound dressing with medical material potential.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20401 - Chemical engineering (plants, products)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Industrial and Engineering Chemistry

  • ISSN

    1226-086X

  • e-ISSN

  • Volume of the periodical

    119

  • Issue of the periodical within the volume

    MAR

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    404-413

  • UT code for WoS article

    000925639200001

  • EID of the result in the Scopus database

    2-s2.0-85143888373