Electron-Beam Irradiation of the PLLA/CMS/beta-TCP Composite Nanofibers Obtained by Electrospinning

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F20%3A00007784" target="_blank" >RIV/46747885:24620/20:00007784 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2073-4360/12/7/1593" target="_blank" >https://www.mdpi.com/2073-4360/12/7/1593</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym12071593" target="_blank" >10.3390/polym12071593</a>

Result language

angličtina

Original language name

Electron-Beam Irradiation of the PLLA/CMS/beta-TCP Composite Nanofibers Obtained by Electrospinning

Original language description

Nanofibrous materials produced by electrospinning processes have potential advantages in tissue engineering because of their biocompatibility, biodegradability, biomimetic architecture, and excellent mechanical properties. The aim of the current work is to study the influence of the electron beam on the poly L-lactide acid/ carboxy-methyl starch/beta-tricalcium phosphate (PLLA/CMS/beta-TCP) composite nanofibers for potential applications as bone-tissue scaffolds. The composite nanofibers were prepared by electrospinning in the combination of 5%v/vcarboxy-methyl starch (CMS) and 0.25 wt% of beta-TCP with the PLLA as a matrix component. The composites nanofibers were exposed under 5, 30, and 100 kGy of irradiation dose. The electron-beam irradiation showed no morphological damage to the fibers, and slight reduction in the water-contact angle and mechanical strength at the higher-irradiation doses. The chain scission was found to be a dominant effect; the higher doses of electron-beam irradiation thus increased the in vitro degradation rate of the composite nanofibers. The chemical interaction due to irradiation was indicated by the Fourier transform infrared (FTIR) spectrum and thermal behavior was investigated by a differential scanning calorimeter (DSC). The results showed that the electron-beam-induced poly L-lactide acid/carboxy-methyl starch/beta-tricalcium phosphate (PLLA/CMS/beta-TCP) composite nanofibers may have great potential for bone-tissue engineering.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/EF16_019%2F0000843" target="_blank" >EF16_019/0000843: Hybrid Materials for Hierarchical Structure</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymers

ISSN

2073-4360

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

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UT code for WoS article

000558024900001

EID of the result in the Scopus database

2-s2.0-85088297588