Bistability in self-activating genes regulated by non-coding RNAs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47813059%3A19240%2F14%3A%230005516" target="_blank" >RIV/47813059:19240/14:#0005516 - isvavai.cz</a>
Result on the web
<a href="http://stacks.iop.org/1742-6596/574/i=1/a=012164" target="_blank" >http://stacks.iop.org/1742-6596/574/i=1/a=012164</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1742-6596/574/1/012164" target="_blank" >10.1088/1742-6596/574/1/012164</a>

Result language
angličtina
Original language name
Bistability in self-activating genes regulated by non-coding RNAs
Original language description
Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is an important behaviour of genetic networks. Here, we propose and study an ODE model in order to show how non-coding RNA can produce bistability in a simple way. The model comprises a single gene with positive feedback that is repressed by non-coding RNA molecules. We show how the values of all the reaction rates involved in the model are able to control the transitions between the high and low states. This new model can be interesting to clarify the role of non-coding RNA molecules in genetic networks. As well, these results can be interesting in synthetic biology for developing new genetic memories and biomolecular devices based on non-coding RNAs.
Czech name
—
Czech description
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Project
<a href="/en/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: IT4Innovations Centre of Excellence</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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