A Self‐Controlled and Self‐Healing Model of Bacterial Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47813059%3A19240%2F22%3AA0001001" target="_blank" >RIV/47813059:19240/22:A0001001 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2077-0375/12/7/678" target="_blank" >https://www.mdpi.com/2077-0375/12/7/678</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/membranes12070678" target="_blank" >10.3390/membranes12070678</a>

Result language

angličtina

Original language name

A Self‐Controlled and Self‐Healing Model of Bacterial Cells

Original language description

A new kind of self‐assembly model, morphogenetic (M) systems, assembles spatial units into larger structures through local interactions of simpler components and enables discovery of new principles for cellular membrane assembly, development, and its interface function. The model is based on interactions among three kinds of constitutive objects such as tiles and protein‐like elements in discrete time and continuous 3D space. It was motivated by achieving a balance between three conflicting goals: biological, physical‐chemical, and computational realism. A recent example is a unified model of morphogenesis of a single biological cell, its membrane and cytoskeleton formation, and finally, its self‐reproduction. Here, a family of dynamic M systems (Mbac) is described with similar characteristics, modeling the process of bacterial cell formation and division that exhibits bacterial behaviors of living cells at the macro‐level (including cell growth that is self‐controlled and sensitive to the presence/absence of nutrients transported through membranes), as well as self‐healing properties. Remarkably, it consists of only 20 or so developmental rules. Furthermore, since the model exhibits membrane formation and septic mitosis, it affords more rigorous definitions of concepts such as injury and self‐healing that enable quantitative analyses of these kinds of properties. Mbac shows that self‐assembly and interactions of living organisms with their environments and membrane interfaces are critical for self‐healing, and that these properties can be defined and quantified more rigorously and precisely, despite their complexity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Membranes

ISSN

2077-0375

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

1-16

UT code for WoS article

000833792100001

EID of the result in the Scopus database

2-s2.0-85133703268