Preparation and conformational study of 19β,28-epoxy-18α-olean-5-ene derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23420%2F06%3A00000008" target="_blank" >RIV/49777513:23420/06:00000008 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preparation and conformational study of 19β,28-epoxy-18α-olean-5-ene derivatives
Original language description
New oleanane type triterpenoids with the 5(6) double bond were prepared using partial demethylation on carbon C-4. The starting compound was 23-hydroxybetulin and the key reaction was the methylation of 19ß,28-epoxy-24-nor-18α-olean-4-en-3-one. The5(6) double bond was used in preparation of new derivatives with an epoxy or oxo substituent in ring B. The conformation of ring A of new type 3-oxo oleanane derivatives with a double bond or a substituent on ring B was elucidated from vicinal coupling constants of hydrogen atoms in positions 1 and 2.
Czech name
Příprava a studium konformace 19β,28-epoxy-18α-olean-5-en derivátů
Czech description
Byl připraven nový typ triterpenoidního oleananu s 5(6) dvojnou vazbou pomocí částečné demethylace uhlíku C-4. Výchozí sloučeninou byl 23-hydroxybelutlin a klíčovou reakcí byla methylace 19ß,28-epoxy-24-nor-18α-olean-4-en-3-onu.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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