How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F11%3A43898377" target="_blank" >RIV/49777513:23520/11:43898377 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00365082 RIV/00216208:11140/11:10103117
Result on the web
<a href="http://dx.doi.org/10.1016/j.jtbi.2011.07.004" target="_blank" >http://dx.doi.org/10.1016/j.jtbi.2011.07.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jtbi.2011.07.004" target="_blank" >10.1016/j.jtbi.2011.07.004</a>

Result language
angličtina
Original language name
How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels
Original language description
In our study, we present a novel p(chi2) (chi-square) method for evaluating the anisotropy of line systems that involves comparing the observed length densities of lines with the discrete uniform distribution of an isotropic line system with the chi2-test. Using this method in our open source software, we determined the rose of directions, preferential directions and level of anisotropy of linear systems representing the microscopic blood vessels in samples of various regions from human brains (cortex,subcortical gray matter and white matter). The novel method was compared with two other methods used for anisotropy quantification (ellipsoidal and fractional anisotropy). All three methods detected different levels of anisotropy of blood microvessels inhuman brain. The microvascular bed in the cortex was closer to an isotropic network, while the microvessels supplying the white matter appeared to be an anisotropic and direction-sensitive system.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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