A Scalable Method for Efficient Stem Cell Donor HLA Genotype Match Determination
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F14%3A43923175" target="_blank" >RIV/49777513:23520/14:43923175 - isvavai.cz</a>
Result on the web
<a href="http://www.europment.org/library/2014/prague/bypaper/EEED-BIO/EEED-BIO-04.pdf" target="_blank" >http://www.europment.org/library/2014/prague/bypaper/EEED-BIO/EEED-BIO-04.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A Scalable Method for Efficient Stem Cell Donor HLA Genotype Match Determination
Original language description
Finding suitable stem cell donors comprises three independent processes: donor pool HLA typing, donor HLA haplotype inference, and search for donor HLA genotype matches. For practical and technical reasons, these processes are often decoupled leading to informational losses along the way. A method is presented that eliminates some of the technical challenges by considering all three steps together. The method relies on two practical assumptions: there exists a set of common haplotypes and the matched target is typed at high resolution. Under these two assumptions, sufficient statistical HLA analysis of a stem cell donor pool is performed to identify donors that most likely match a given genotype. The presented common haplotype Expected-Maximization (chEM) method is scalable in the number of loci, the number of alleles, and typing ambiguity, overcoming the known curse of dimensionality for the problem of HLA haplotype inference. The practical value is demonstrated on real world data provided by the Czech National Marrow Donor Registry. It is shown the chEM method significantly reduces the field of potential matches when compared to an existing match algorithm.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20205 - Automation and control systems
Result continuities
Project
<a href="/en/project/TA01010342" target="_blank" >TA01010342: Research and development of advanced IT technologies for support of bone marrow donor searching for transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Energy, Environment, Biology and Biomedicine
ISBN
978-1-61804-232-3
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
28-32
Publisher name
Neuveden
Place of publication
Neuvedeno
Event location
Prague
Event date
Apr 2, 2014
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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