Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F18%3A43955022" target="_blank" >RIV/49777513:23520/18:43955022 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/19:00506014 RIV/61388971:_____/19:00506014 RIV/61388963:_____/19:00506213 RIV/00216208:11110/19:10394469 and 2 more
Result on the web
<a href="http://doi.org/10.1007/s12010-018-2899-8" target="_blank" >http://doi.org/10.1007/s12010-018-2899-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12010-018-2899-8" target="_blank" >10.1007/s12010-018-2899-8</a>
Alternative languages
Result language
angličtina
Original language name
Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination
Original language description
Type 2 diabetes mellitus (T2DM) is a major epidemiological problem. Metformin and vildagliptin are well-established antidiabetic drugs. The aim of the study was to evaluate the changes of plasma metabolic profile induced by a high-fat diet (HFD) and subsequent oral administration of metformin, vildagliptin, and their combination in a mouse model of diet-induced obesity (DIO)/T2DM analyzed using quadrupole-time-of-flight mass spectrometry (qTOF-MS). Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice. Vildagliptin treatment increased levels of butyrylcarnitine and acetylcarnitine. In summary, our metabolomics study revealed multiple differences between obese diabetic HFD mice and lean standard chow diet (SCD) mice, which were partially modifiable by subsequent metformin and vildagliptin treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
ISSN
0273-2289
e-ISSN
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Volume of the periodical
188
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
165-184
UT code for WoS article
000467534600013
EID of the result in the Scopus database
2-s2.0-85056076757