The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295793" target="_blank" >RIV/00216208:11110/15:10295793 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10295793

Result on the web

<a href="http://dx.doi.org/10.1002/dmrr.2636" target="_blank" >http://dx.doi.org/10.1002/dmrr.2636</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/dmrr.2636" target="_blank" >10.1002/dmrr.2636</a>

Result language

angličtina

Original language name

The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice

Original language description

BackgroundInfection with Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, results in chronic infection that leads to cardiomyopathy with increased mortality and morbidity in endemic regions. In a companion study, our group found thata high-fat diet (HFD) protected mice from T.cruzi-induced myocardial damage and significantly reduced post-infection mortality during acute T.cruzi infection. MethodsIn the present study metabolic syndrome was induced prior to T. cruzi infection by feeding a high fat diet. Also, mice were treated with anti-diabetic drug metformin. ResultsIn the present study, the lethality of T.cruzi (Brazil strain) infection in CD-1 mice was reduced from 55% to 20% by an 8-week pre-feeding of an HFD to induce obesityand metabolic syndrome. The addition of metformin reduced mortality to 3%. ConclusionsIt is an interesting observation that both the high fat diet and the metformin, which are known to differentially attenuate host metabolism, effectively

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes/Metabolism Research and Reviews [online]

ISSN

1520-7560

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

346-359

UT code for WoS article

000353396700004

EID of the result in the Scopus database

2-s2.0-84928209062