Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F24%3A43973076" target="_blank" >RIV/49777513:23640/24:43973076 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.cis.2024.103163" target="_blank" >https://doi.org/10.1016/j.cis.2024.103163</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cis.2024.103163" target="_blank" >10.1016/j.cis.2024.103163</a>

Result language

angličtina

Original language name

Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review

Original language description

Repairing and regenerating damaged tissues or organs, and restoring their functioning has been the ultimate aim of medical innovations. &apos;Reviving healthcare&apos; blends tissue engineering with alternative techniques such as hydrogels, which have emerged as vital tools in modern medicine. Additive manufacturing (AM) is a practical manufacturing revolution that uses building strategies like molding as a viable solution for precise hydrogel manufacturing. Recent advances in this technology have led to the successful manufacturing of hydrogels with enhanced reproducibility, accuracy, precision, and ease of fabrication. Hydrogels continue to metamorphose as the vital compatible bio-ink matrix for AM. AM hydrogels have paved the way for complex 3D/4D hydrogels that can be loaded with drugs or cells. Bio-mimicking 3D cell cultures designed via hydrogel-based AM is a groundbreaking in-vivo assessment tool in biomedical trials. This brief review focuses on preparations and applications of additively manufactured hydrogels in the biomedical spectrum, such as targeted drug delivery, 3D-cell culture, numerous regenerative strategies, biosensing, bioprinting, and cancer therapies. Prevalent AM techniques like extrusion, inkjet, digital light processing, and stereo-lithography have been explored with their setup and methodology to yield functional hydrogels. The perspectives, limitations, and the possible prospects of AM hydrogels have been critically examined in this study.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advances in Colloid and Interface Science

ISSN

0001-8686

e-ISSN

1873-3727

Volume of the periodical

328

Issue of the periodical within the volume

JUN 2024

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

34

Pages from-to

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UT code for WoS article

001241312000001

EID of the result in the Scopus database

2-s2.0-85192792764