Chitosan and its derivatives as nanotheranostics in multiple diseases management: a clinical perspective
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F25%3A43976027" target="_blank" >RIV/49777513:23640/25:43976027 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.carbpol.2025.123852" target="_blank" >https://doi.org/10.1016/j.carbpol.2025.123852</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2025.123852" target="_blank" >10.1016/j.carbpol.2025.123852</a>
Alternative languages
Result language
angličtina
Original language name
Chitosan and its derivatives as nanotheranostics in multiple diseases management: a clinical perspective
Original language description
Chitosan, a biopolymer derived from chitin, has garnered substantial scrutiny in recent times, attributable to its versatile properties, including biodegradability, biocompatibility, and non-toxicity. These characteristics make it an ideal candidate for various medical applications, particularly in the field of nanomedicine. This review explores the emerging role of chitosan and its derivatives in nanotheranostics, which combines therapeutic and diagnostic modalities for the treatment of multiple diseases. The prospect of chitosan-based nanoparticles in the delivery of drugs, vector delivery, imaging, and disease monitoring has been extensively explored. The modification of chitosan with various functional groups, such as chitosan oligosaccharides, thiolated chitosan, carboxymethyl chitosan, glycol chitosan and other derivatives, enhances its pharmacokinetic properties, targeting capabilities, and therapeutic efficacy. Chitosan-based nanocarriers have shown potential in treating various conditions, including cancer, inflammation, infectious diseases, and neurodegenerative disorders, by improvingthe solubility of drugs, stability, and controlled release. Additionally, chitosan has a theranostic role in imaging approaches such as optical imaging, ultrasound, and photoacoustic imaging, facilitating early diagnosis and monitoring of therapeutic responses. This review also addresses the disputes and future perceptions for the development of chitosan-based nanotheranostics, including issues related to scalability, regulatory approval, and long-term safety.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CARBOHYDRATE POLYMERS
ISSN
0144-8617
e-ISSN
1879-1344
Volume of the periodical
366
Issue of the periodical within the volume
OCT 15 2025
Country of publishing house
GB - UNITED KINGDOM
Number of pages
28
Pages from-to
nestránkováno
UT code for WoS article
001510788400003
EID of the result in the Scopus database
2-s2.0-105007707325