Analysis of Genetic Damage in Lymphocytes of Former Uranium Processing Workers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F15%3A43889944" target="_blank" >RIV/60076658:12110/15:43889944 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00458998

Result on the web

<a href="http://dx.doi.org/10.1159/000441889" target="_blank" >http://dx.doi.org/10.1159/000441889</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000441889" target="_blank" >10.1159/000441889</a>

Result language

angličtina

Original language name

Analysis of Genetic Damage in Lymphocytes of Former Uranium Processing Workers

Original language description

The frequency of cells containing micronuclei (MN) and the presence of centromeres in these MN were analysed in lymphocytes of 98 men from Southern Bohemia. 46 of them had worked at the uranium processing plant, "MAPE Mydlovary", which has been defunct since 1991; 52 men were controls from the same area. Fluorescence in situ hybridization (FISH) method using Human Pan Centromeric Chromosome Paint was employed to recognize centromere positive (CEN+) and negative (CEN-) micronuclei. A total of 1000 binucleate cells (BNC) per participant were analysed after cytochalasin B treatment. All BNC with MN (centromere positive or negative) were recorded by the ISIS software (MetaSystems). No differences were found between formerly exposed workers and the controlgroup, neither in the total frequency of cells with MN per 1000 BNC (mean levels +- standard deviation were 9.1+-3.1 and 9.8+-2.5, resp.), nor in the percentage of CEN- among all MN was nearly equal for both groups (50+-18 and 49+-17, res

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytogenetic and Genome Research

ISSN

1424-8581

e-ISSN

—

Volume of the periodical

147

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

17-23

UT code for WoS article

000370491200003

EID of the result in the Scopus database

—